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Notably, most clinical investigations studied women (1404 female versus 83 male participants), which is expected since estrogen declines after age 30 years, and further estrogen decline with aging represents health challenges, as well as a reduction in QOL [9, 10, 19,20,21,22] and a degradation in the most visible organ of the bodythe skin [9, 10]
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For more information about FDAs posting of comments to public dockets, see 80 FR 56469, September 18, 2015, or access the information at: Federal Register/Vol
