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Combining these endpoints gives a clearer picture than relying on one assay alone

Despite early scientific interest, no major modern clinical development program, large contemporary randomized trials, or high-quality meta-analyses were identified

This finding is consistent with previous studies that have demonstrated HIF-1 activation as a key mechanism underlying enhanced cell survival and regenerative capacity in MSCs under hypoxic conditions (Mahjoor et al., 2023

doi: 10.1073/pnas.1821306116 207 ChesikDDe KeyserJ

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