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1 In the absence of adequate GSH concentrations, numerous oxidative and nitrosative reactive intermediates persist, including superoxide, hydroxide, peroxide, and peroxynitrite radicals, which all can lead to modification of cellular macromolecules including lipid membranes (measured in vivo by F2-isoprostanes) and DNA adduct formation (measured in vivo by 8-hydroxy-2-deoxyguanosine [8-OHdG])
5683 in Sahih Al-bukhari book
An additional problem with the analysis of data obtained from databases, such as the DNBC, is evident in the systematic review described above
While short-term use at moderate doses appears safe for most people, the effects of prolonged mega-dosing haven't been comprehensively studied
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1995;269:E551-E556 121
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