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In fact, human studies on GHK-Cu have mainly used the topical route of administration

It impairs recovery from training

[DOI] [PMC free article] [PubMed] [Google Scholar] 41

However, long-term NNMT inhibition in humans hasn't been characterized beyond small pilot cohorts, so concerns about sustained NAD+ elevation (which could theoretically promote certain cancers via PARP or SIRT activation) remain speculative but unresolved