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Does long-term consumption of 500mg of Glutathione (GSH) have serious side effects, particularly on liver and kidney function?

One of the most commonly used experimental models of IBD is the administration of an enema containing the contact-sensitizing allergen trinitrobenzenesulfonic acid (TNBS) in ethanol resulting in the development of macroscopic, histologic, and biochemical alterations that are well-characterized (Rachmilewitz et al, 1989

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Dose adjustments may be necessary, accompanied by periodic evaluation of clinical response and tolerability