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10.1016/S1570-0232(03)00399-4 Summary Keywords acetaminophen, reactive metabolite, covalent binding, glutathione S -transferase, bottom-up proteomics, data-dependent acquisition, high-resolution tandem mass spectrometry, multiple reaction monitoring Citation Geib T, Lento C, Wilson DJ and Sleno L (2019) Liquid Chromatography-Tandem Mass Spectrometry Analysis of Acetaminophen Covalent Binding to Glutathione S -Transferases

In some cases, people may experience mild symptoms like nausea, rashes, or itching

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Rapid progression also prevents accurate assessment of what concentration actually delivers results

Therefore, BSO clinical use is restricted by its short half-life, with the consequent need for prolonged infusions resulting in its nonselective effect of GSH depletion on both normal and malignant cells [63]

doi: 10.1124/mol.106.024778