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But why, I ask, are there no gold-standard trials on humans

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doi: 10.1021/acs.chemrestox.9b00028 11 CheahI

Further, overproduction of free radicals have also been shown to occur due to spontaneous breakdown (autoxidation) and/or excessive metabolism by monoamine oxidase of adrenaline, noradrenaline and dopamine, which can further overwhelm the brains antioxidant systems (Cohen, 1984

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Two trials have supported an increase in the risk of all types of thyroid carcinoma [200,201]