When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways
Population Limitations: As noted previously, the trials did not include elderly individuals, pregnant women, children, or those with certain medical conditions
Clinical access is the saving grace, since every refill requires a real consultation, and you can pick phone or async
References 1 JiangY-JChengY-HZhuH-QWuY-LNanJ-XLianL-H
doi: 10.1016/j.neuron.2015.09.038 111 O'NeilP
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