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It is important to note that headaches can occur for numerous reasons unrelated to medication, including stress, dehydration, dietary changes, caffeine withdrawal, or pre-existing conditions such as migraine or tension-type headache

Key symptoms include: Fatigue: A pervasive sense of tiredness that does not improve with rest

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10.1093/cvr/cvad095 28 GrellnerW.GeorgT.WilskeJ

This spreading might mean it becomes harder to treat over time and could lead to more serious symptoms

Week two: establish consistency If week one went well, increase to daily evening application