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The substantial cardiovascular benefits observed with SGLT2 inhibitors (55% reduction in heart failure hospitalization) and GLP-1 receptor agonists (35% reduction in major adverse cardiovascular events) highlight the need to align treatment with broader cardiorenal-metabolic risk profiles, rather than focusing exclusively on glycemic control

American Psychiatric Pub

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PMID: 49 ZhaoTFangRDingJLiuYChengMZhouFet al

JAMA Cardiol 2020, 5(10): 1182-1190

PT-141 acts earlier in that sequence, at the level of central melanocortin receptors, making it the more relevant option when the core issue is drive rather than physical response