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Supplementary Materials Data Availability Statement The original contributions presented in the study are included in the article/supplementary material.

The gap between the 9 mg and 12 mg arms is narrow (about 2.3 percentage points) relative to the gap between either active arm and placebo, a pattern that has implications for dose selection in a real-world setting

GLP-1 (glucagon-like peptide-1) is a hormone your body naturally produces that plays a role in appetite regulation, fullness, and blood sugar control

Antimicrobials like berberine can kill both good and bad bacteria

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