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Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

Here is the connection: The NNMT enzyme destroys the precursors needed to make NAD+

After 24 weeks, Mini-Mental State Examination (MMSE) scores didnt significantly improve in the treatment groups compared to the placebo, and the placebo group actually improved significantly more than the B12-only group (Eussen, 2006)

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