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Spiral wave reentry, often visualized as rotors, represents a major pathophysiological concept in AF and rotor ablation has been suggested as a potential ablation strategy of persistent AF [19, 20], which is presently evaluated in various clinical trials (ClinicalTrials.gov numbers: NCT02101541, NCT02274857, NCT01924377, NCT02386345, NCT02497248, NCT02113761)