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273 In addition, in a rat model of inflammatory OA induced by monoiodoacetic acid (MIA), researchers have shown that the activation of GLP-1R triggers the PKA/CREB signaling pathway, leading to a reduction in cartilage inflammation

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Running alongside these is TRIUMPH-CVOT, a separate cardiovascular outcomes trial enrolling around 10,000 participants with established cardiovascular disease over 3-4 years

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The current evidence is therefore insufficient to support therapeutic claims for 5-Amino-1MQ in people

5 Still, this research shows what happens when you stop the medications suddenly without a gradual decrease in dose (a taper), and with adequate lifestyle support alongside it