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YTHDF1 knockdown significantly down-regulated cytochrome C, while up-regulating Ferritin, TFAM and GPX4 (Fig

The limited availability of free CoA leads to the arrest of the beta-oxidation process and to the accumulation of harmful long-chain acylCoA and acylcarnitines in the mitochondria

The main pool of reactive oxygen and nitrogen species is free radicals

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doi: 10.1161/jaha.119.015716