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The renal benefit was attenuated in HFpEF populations (HR: 0.60 vs 0.94

Currently, the FDA has not approved semaglutide specifically for weight loss in patients under 18 years old, though limited clinical data exists for adolescent use in diabetes management

[9] [10] For patients with established cardiovascular disease, SGLT2 inhibitors are generally prioritised for cardiorenal protection, with GLP-1 receptor agonists with proven cardiovascular benefit considered when SGLT2 inhibitors are unsuitable

GLP-1 medications are a modern, evidence-based approach to weight management that work by regulating appetite, improving satiety, and helping patients reduce overall caloric intake without extreme dieting or unsafe stimulant use

This is always important, but especially when youre experiencing digestive side effects

Front Psychiatry 12 , 739 (2021)