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Variants in genes encoding glutathione-synthesis enzymes (like GCLC or GSS) or detoxification machinery may indicate stronger biological rationale for considering glutathione intervention

[15] Lu, S.C

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The best-known predictors of success are end-stage fibrotic bladder, 230 231 small bladder capacity under anesthesia 230, 232-236 231 and presence of Hunner lesions

These observations suggest that AOD9604 may interact with cartilage metabolism and joint remodeling pathways, making it a candidate tool for investigating chondrocyte activity, matrix turnover, and osteoarthritic progression in preclinical models

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