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The SURPASS-2 trial, which directly compared tirzepatide 15mg to semaglutide 1mg, found tirzepatide produced greater reductions in LDL cholesterol (11.4% vs 7.9%) and triglycerides (23.5% vs 16.2%) at 40 weeks

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5-Amino-1MQ inhibits NNMT, an enzyme that depletes NAD+ and promotes fat storage