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Table 18: Percent Change from Baseline in BMI after 52 Weeks of IMCIVREE Treatment in Patients Aged 2 to Less Than 6 Years with Obesity due to POMC Deficiency, LEPR Deficiency, or BBS (Trial 5) Supportive of IMCIVREEs effect on weight loss, general numeric improvements in waist circumference were observed

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Th17 and Th1 cells influence astrocyte functions, downregulating neurotrophic factors and upregulating inflammatory cytokines and chemokines [265]

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