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doi: 10.1016/j.tem.2020.02.006 64 IrwinNMcCleanPLCassidyRSOHarteFPMGreenBDGaultVAet al

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Abbreviations WHO: World Health Organization TAK1: Transforming growth factor- -activated kinase 1 MO: Moringa oleifera AGE: Advanced Glycation Endproducts MyD88: Myeloid differentiation primary response protein TNF- : Tumor Necrosis Factor- IKKB: Inhibitory kB kinase beta RAGE: Advanced glycation endproduct receptor NQO1: NAD(P)H quinone dehydrogenase ROS: Reactive oxygen species CAT: Catalase HO-1: Heme oxygenase-1 SOD: Sodium dismutase NOX: NADPH-oxidase IKK: Inhibitory KB kinase alpha TRAF6: TNF receptor-associated factor 6 Keap1: Kelch-like ECH associated protein 1 LPS: Lipopolysaccharides MCP-1: Monocyte chemoattractant protein Nrt2: Nuclear factor erythroid 2-related factor 2 TLR4: Toll-like receptor 4 NFB: Nuclear factor kappa-light-chain-enhancer of activated B cells Nrf2: Nuclear factor erythroid 2-related factor 2 Keap: Kelch-like ECH-associated protein 1 ARE: Antioxidant response element

Copper peptides and retinol Retinol and copper peptides present a different challenge

Using them in sequence (lighter AHK-Cu spray first, followed by GHK-Curich creams or serums) allows each peptide to optimize a different aspect of skin biology

and Food Res