Although not a focus of the report here, we recently found that JWU-A021 failed to stimulate GLP-1 release from GLUTag cells, a mouse L-cell line 28
"With orforglipron, we're working to transform obesity care by introducing a potential once-daily oral therapy that could support early intervention and long-term disease management, while offering a convenient alternative to injectable treatments," Kenneth Custer, an executive vice president and president of Lilly Cardiometabolic Health, said in a statement
Enhanced satiety signals (better control over cravings)
By acting on your brain, stomach, and blood sugar systems at the same time, GLP-1 medications can support meaningful weight loss and improve metabolic health over time, she says
Akkermansia abundance correlates with improved markers of metabolic inflammation (Plovier et al., 2017, Nature Medicine )
GLP-1 medications are excellent for reducing the size of fat cells, but they dont alter the underlying structure of your skin