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Mechanism of Action FOXO4-DRI has been investigated for its selective disruption of the FOXO4-p53 protein-protein interaction in senescent cells

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The disadvantage is the metabolic disruption of stopping and starting, which may reduce the efficiency of subsequent treatment courses

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Neutrophilia causes excessive ROS production that aggravates the host immunopathological response, leading to a more severe disease (Laforge et al., 2020)