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In this trial, the safety and tolerability of sitagliptin were generally similar to placebo

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Potential Interactions and Safety Considerations Retatrutide's multi-receptor activity creates clinically significant interaction risks, including hypoglycaemia with insulin or sulphonylureas, worsened gastrointestinal effects, pancreatitis, gallbladder disease, and dehydration-related acute kidney injury

Trends Biochem Sci (2017) 42(8):62539

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