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Although these therapeutic strategies are still in development, they have the potential to suppress ALS progression by directly targeting specified glial cell populations, applying Treg, and suppressing age-associated chronic inflammation (Gendron and Petrucelli, 2023)

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Conversely, the proinflammatory and profibrotic reactions in adult mammals contribute to scar formation and hinder cardiomyocyte proliferation 43,44

Adherence varies by patient

Female sex [2], obesity [3], and higher dermal nerve fiber regeneration [15] have been suggested as risk factors for painful DPN compared with painless DPN

Antibodies targeting tumor vessel markers have also been used