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However, these synthetic DPP-IV inhibitors have been reported to have a number of adverse effects, such as gastrointestinal adverse reactions, allergic reactions, skin-related side effects, and musculoskeletal disorders

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Conclusions In addition to the conventional mechanism of desensitization, which occurs on the plasma membrane and in the cytosol, this study provides a new insight that another desensitization pathway in which nuclear trafficking plays a critical role is operating