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This is the first placebo-controlled randomised, double-blind trial of a tablet containing the combination of ALA, SOD, B12, and ALC as a food supplement that investigated the efficacy of the tablet on all three major forms of chronic generalized DN, i.e., peripheral sensorimotor neuropathy, autonomic neuropathy, and painful neuropathy

N Engl J Med 345(12):851860 Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving H-H et al (2001Effects) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

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doi: 10.1093/stmcls/sxad074 40 WangYWangLMaSChengLYuG

NADH then donates these electrons to the electron transport chain, converting them back to NAD+ to continue the cycle