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In the Phase 2 clinical trial published in The New England Journal of Medicine in 2023, gastrointestinal side effects affected the majority of participants, with nausea, vomiting, diarrhea, and constipation being the most frequent complaints

doi: 10.1016/j.mhpa.2020.100345 119 StantonRToQGKhalesiSWilliamsSLAlleySJThwaiteTLet al

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Early prototypes have demonstrated 90% accuracy in correlating BP with endothelial dysfunction in animal models (Zhang et al., 2023)

For example, a 12-week study of patients randomized to olanzapine 15 mg plus metformin 750 mg (n = 20), vs olanzapine 15 mg plus placebo (n = 20), found that the 63% of patients taking olanzapine + placebo increased their weight by more than 7% vs only 17% of patients taking olanzapine + metformin (Wu RR et al, Am J Psychiatry 2008;165(3):352358)