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Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis 1

Appetite suppression, a key effect of these drugs, is leading to changes in consumer behavior

But each also requires more careful starting dose management

In addition, the presence of major pharmaceutical companies and ongoing innovation in drug development and delivery technologies have boosted North Americas leadership position in this space

Side effect-wise, it's the same

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