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The treatment normalized neurotransmitter levels (norepinephrine, dopamine, serotonin), highlighting its potential in ameliorating AD-like symptoms (Anwar et al., 2021)

doi:10.1016/S0969-2126(02)00906-1

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Due to MTII's broad, non-selective receptor activity, researchers and regulatory agencies have raised concerns about potential effects on melanocytic nevi (moles) and theoretical melanoma risk through excessive MC1R stimulation