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Senescent cells promote tissue NAD decline during ageing via the activation of CD38 macrophages

A critical gap is the identification of definitive molecular switches that determine whether the crosstalk promotes tumor cell survival or death in a given therapeutic setting, which severely impedes the rational design of pathway-specific modulators

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Mauriz (1,2) (1) Institute of Biomedicine (IBIOMED), University of Len, Len, Spain