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However, oral semaglutide (Rybelsus) increases levothyroxine exposure by approximately 33% according to FDA labeling, and all semaglutide formulations slow gastric emptying, potentially affecting levothyroxine absorption

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10.3390/neurolint16030037 15 BejE.VolpeA

Janku F, De Groot JF, Javle MM, Penas-Prado M, Shroff RT, Luthra R, Banks K, Lanman RB, Conley AP, Broaddus R, Davies MA, Kopetz S , Yung WKA, Heymach J, Fu S, Shaw KR, Meric-Bernstam F

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Oral semaglutide (Rybelsus) requires specific administration instructions: taking on an empty stomach with a small amount of water and waiting at least 30 minutes before consuming food, beverages, or other medications