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It also calls the evidence for lipotropic efficacy generally mixed, with most support observational rather than from large randomized trials

Kov L, Dadkov K, Kaparovsk J, Kaparovsk T, Isoflavones

Copper is a required cofactor for lysyl oxidase (connective-tissue crosslinking), for superoxide dismutase (antioxidant defense), and for enzymes that support angiogenesis, so a molecule that delivers copper in a controlled, cell-usable form has a coherent reason to influence tissue remodeling and vascular biology

The long-term success of intermittent treatment with rapalogs [183] still remains to be fully evaluated

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DOI: 10.1056/NEJMoa1411481 Biolcati G et al