Age eligibility for this off-label use remains a conversation between patient and provider, with most guidance recommending the same 18+ threshold seen in diabetes populations
In recent works, the study demonstrated that GCH1/ BH4 pathic enzyme dihydrofolate reductase (DHFR) could inhibit ferroptosis by generating BH4, so decrease in DHFR activity reduces BH4 content to enhance lipid peroxidation and sensitizes cells to ferroptosis (Lu et al., 2024), but the detail process is still unknown (Figure 1)
Having this guidance increases your chances of keeping the weight off long term
The regulation of CSE is not very well understood, yet
This is where subtlety, balance, and homeostasis matter
Again, these compounded versions of the medication are not always FDA-approved