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doi: 10.1093/cid/ciaa329

Thus, although GIPR in the AP is required for the weight loss effects of GIPR agonists, it is not the target of therapeutic GIPR antagonists, supporting recent findings that Gipr KO in GABAergic neurons also abolished responses to GIPR agonism but not antagonism 6

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Does specific activity of a recombinant protein vary between lots

Recently, the discovery of reversible/irreversible covalent inhibitors targeting cysteine residues in and around the ATP-binding pocket of kinases has been gaining considerable attention (94)