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Tirzepatidewhich activates both GLP-1 and GIP receptorsshowed even greater efficacy in the SURMOUNT trials, with some participants achieving weight reductions exceeding 20%

Treatment should complement rather than replace lifestyle modifications, with multidisciplinary support including dietetic input, psychological support, and regular medical monitoring essential for optimal outcomes

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Melting curve analysis was performed to confirm the production of a single product in each reaction

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