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In the context of ADRD risk, cerebral hypoperfusion also appears to precede Amyloid- (A) and hyperphosphorylated tau accumulation in the ADRD pathophysiological cascade (Iturria-Medina et al., 2016), particularly in regions vulnerable to early pathology (entorhinal cortex, hippocampus, inferior parietal cortex, inferior temporal cortex) (Mattsson et al., 2014)

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These advancements not only enhance the quality of glutathione but also increase its availability in various forms, such as oral supplements and topical applications

Previous studies reported astaxanthin significantly reduced the content of MDA in preeclamptic rats and trophoblast cell line (Xuan et al., 2014

Thymosin beta-4 promotes cell migration and angiogenic activity in experimental models