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These include alpha-lipoic acid (100 to 200 mg daily), methylsulfonylmethane (MSM) at 500 mg three times a day , and milk thistle supplements rich in silymarin

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In thiamin-responsive individuals, the supplementation has been proven effective to correct the phenotype without recourse to the BCAA restriction diet

It is strategic

[PubMed: 31637820] 372

Biochemical analysis of the cerebrospinal fluid: evidence for catastrophic energy failure and oxidative damage preceding brain death in severe head injury: a case report