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Predicted ploidy changes were validated in 6 patients by fluorescence in situ hybridisation (FISH) using probes against MYC , CDKN2A , and CCND1 , and against centromeres in chromosomes 8, 9 and 11 (r = 0.76, Spearman correlation

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Most patients run an initial protocol of three to six months before reassessment

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