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Li Z, et al

Homocysteine up-regulates hepcidin expression through the BMP6/SMAD pathway, which suggests a novel approach to reset Fe-RH 491

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Deficiency in vitamin B12 may cause anemia, fatigue, muscle weakness, intestinal problems, nerve damage, and mood disturbances

Most importantly, individuals with MS experience severe disabling fatigue [229], with 70% of patients with MS reporting fatigue38% of which describe fatigue to be their most disabling symptom [230]