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Individual variability exists due to genetic differences in gut-hormone sensitivity

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Operates at the nuclear protein-interaction level: Unlike metabolic or hormonal peptides that act on membrane receptors, FOXO4-DRI functions by disrupting nuclear protein interactions

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Boxplot showing increased expression of PC conversion related proteins (PEMT, PISD, and PTDSS2) in primitive compared to committed AML(n = 96 patients)