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mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria
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These effects can contribute to gradual, sustainable results when combined with consistent lifestyle habits
Potential Risks and Side Effects While glutathione is generally considered safe, there are some potential risks associated with supplementation, particularly at high doses
A WHO consultation identified the most vulnerable groups as elderly individuals, infants, preschool-aged children, and pregnant or lactating women, due to either increased nutritional demands or impaired absorption capacity ( Addressing the prevention of B12 deficiency and its public health implications requires a comprehensive, life-course approach based on integrated strategies targeting early detection, dietary optimisation, and effective supplementation, in order to mitigate the long-term consequences of inadequate cobalamin status ( Intramuscular (IM) injection is the most invasive and costly administration method, requiring trained personnel and clinical visits
