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That does not mean patients should assume broad benefits or use products from unverified sources

Significant nerve compression can weaken muscles controlled by the affected nerve root

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In mice, a high-fat diet has also been shown to impair leptin signaling by attenuating STAT3 activation, thus contributing to leptin resistance [18].Leptin receptor activation engages intracellular proteins, such as protein tyrosine phosphatase1 B (PTP1B) and suppressor of cytokine signaling-3, that terminate receptor signaling

Nutrients, 10 (12), 1892

This can happen due to various reasons such as poor diet, absorption issues, or certain medical conditions