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EBRT EBRT has been used for palliation of locally recurrent tumors without evidence that it provides any survival advantage.[10] Locally advanced and metastatic disease Treatment options for locally advanced and metastatic MTC include: Targeted therapy Tyrosine kinase inhibitors Vandetanib Vandetanib is an oral inhibitor of rearranged during transfection (RET) receptor kinase, vascular endothelial growth factor receptor (VEGFR), and epidermal growth-factor receptor

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