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(81) functionally investigated the role of thioredoxin redox proteins ( Txdnc2 and Txdnc3 ) in mice to show that these genes limited oxidative stress ( P 40 years of age compared with those younger than 40 years of age, although a significant relationship between DNA fragmentation and increased paternal age was observed

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Klatsky AL, Armstrong MA

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It also inhibits STAT3 signaling, increases FasL/Fas-mediated apoptosis, and deacetylates STAT3, affecting feedback regulatory loops involved in tumor growth

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