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The Root Causes Menopause insomnia is primarily driven by three physiological changes: declining oestrogen and progesterone (which regulate your sleep cycle and body temperature), elevated evening cortisol (which keeps your nervous system alert), and disrupted gut health (which reduces production of melatonin, your body's natural sleep hormone)

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In the considered dose range of 0.5 to 1 mg kg 1 , AMG 133 demonstrates a long half-life ranging from 189 to 222 h (intact AMG 133 assay) and from 231 to 284 h (total AMG 133 assay)