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Previous studies reporting that GLP-1-based agents suppress microglial activation, inhibit NF-B signalling, and reduce mitochondrial stress [36], further support the notion that Retatrutide may alleviate inflammatory burden, particularly through modulation of TNF-

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By hitting both receptors, tirzepatide produces a more pronounced effect on satiety and glucose control than single-agonist compounds like semaglutide

The STEP 4 trial, which specifically examined continuation versus withdrawal of semaglutide, confirmed substantial weight regain in the discontinuation group

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