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Key molecular chaperonesincluding Hspa5, Hspa8, Hspa1a, Hspa1b, Hspa4l, Hsp90aa1, Hsp90ab1, Hsp90b1, Hsph1, Dnaja1, Dnajb1, Dnajb2, and Dnajb11were significantly suppressed, indicating reduced protein folding capacity

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It has become a focal point in labs and research circles for its potential role in tissue repair and recovery

However, these drugs are very expensive, have not been shown to prevent colectomy in severe ulcerative colitis (Aratari 2008), and may cause autoimmune diseases, cancer, infections, and viral reactivation syndromes including shingles (Colombel 2004)