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DOI: Namazi, F., Shomali, T., Taghikhani, P., & Nazifi, S

There are millions of Americans with type 2 diabetes and many different medications they can be prescribed to treat it, said senior author Patrick OConnor, MD, an investigator at HealthPartners Institute

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195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death