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Itchy skin is observed during the process of inflammation, some metabolic diseases, psychiatric illnesses, drug abuse, stress and various malignancies as well

J Cancer Prev 18(2):186 Yilmaz B, Basar , Aktas B, Altinbas A, Ekiz F, Bykcam F, Albayrak A, Ginis Z, ztrk G, Coban S (2014) Effects of Urtica dioica extract on experimental acute pancreatitis model in rats

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Other research showed that advanced glycation end products (AGE), and receptor of advanced glycation end products (RAGE), induces the release of ROS and stimulates DPP-4 expression from ECs by interacting with the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR) (55)

This is a hard stop before purchase for buyers in those categories - consult your doctor first