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To minimize gastrointestinal side effects, clinicians typically employ gradual dose titration, starting at 2.5 mg weekly and increasing by 2.5 mg increments every 4 weeks based on individual tolerance

Murae M, et al

Similarly, patients with GLP-1 prescriptions in the year after surgery increased from 0.4% in 2018 to 2.3% in 2023

In order to collect a sufficient number of cells for implantation, isolated chondrocytes usually undergo an extensive expansion from 0.10.2 million to 4060 million ( Thus, selectively removing senescent cells in chondrocytes is crucial to assure the quality of cells for ACI

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